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Nanogram-scale MS benchmarks: isotope ratios and reproducible CZE-MS
Two bioRxiv method preprints report benchmarks aimed at extending proteomics-compatible MS into scarce-sample and higher-robustness regimes. One integrates Fourier Transform Isotopic Ratio Mass Spectrometry (FT IsoR MS) with single-cell-style preparation and reports reliable relative δ13C measurements from as few as ~50 HeLa cells (<10 ng protein), while noting that <10 cells are not statistically robust. The other presents an ~170-run CZE-MS dataset to support qualitative and quantitative reproducibility for multi-level proteomics (bottom-up, top-down, native) across E. coli, HeLa, and human plasma, and reports native proteomics detection of hundreds of complexoforms up to 800 kDa while con
Preprints benchmark nanogram-scale isotope-ratio MS and reproducible CZE-MS proteomics
Two bioRxiv method preprints report benchmarks aimed at expanding proteomics-compatible MS into scarce-sample and higher-robustness regimes.
Details
- Both items are newly posted bioRxiv preprints with explicit sensitivity/reproducibility benchmarks
- Single-cell-style prep and nanogram inputs align with increasing limited-sample study designs
- A large (~170-run) series directly addresses robustness concerns for CZE-MS workflows
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