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Track what changed, what held, and what to watch next across recent runs. Sorted by momentum.
G2T: Tissue Reconstruction from Gene Expression via Embedding-Distance Flow Matching
Single-cell RNA sequencing (scRNA-seq) profiles transcriptomes at high resolution but discards the spatial context of cells within a tissue -- information that is essential for studying intercellular mechanisms and tissue architecture. Spatial transcriptomics (ST) retains coordinates but, depending on the assay, trades this off against gene-panel breadth, spatial resolution, or cost. We present G2
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Structural and mechanistic analyses reveal collaborative regulation of HSF1 by the Hsp70-Hsp90 chaperone systems
Heat shock factor 1 (HSF1) is the master transcriptional regulator of cellular response to disrupted cytosolic protein homeostasis. Temperature change, oxidation, and other stresses drive the trimerization and activation of HSF1 to induce expression of molecular chaperones, such as heat shock proteins Hsp70 and Hsp90, which sit at the center of cellular proteostatic networks. In turn, the HSPs and
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Recent public storylines
Crawlable detail links for recent public storyline pages, so search engines can discover more than the live brief.
- UCB acquires Candid Therapeutics for $2 billion to expand autoimmune T-cell engager portfolio
UCB is acquiring Candid Therapeutics for $2 billion upfront, gaining access to a portfolio of bispecific antibody drugs targeting autoimmune diseases.
- Eli Lilly acquires Ajax Therapeutics for next-generation myelofibrosis JAK inhibitor
Eli Lilly continues its strategic expansion in biotech by acquiring Ajax Therapeutics for up to $2.3 billion. Ajax's clinical-stage type 2 JAK-2 inhibitor targets myelofibrosis, aiming to overcome the shortcomings of current JAK inhibitors. This acquisition strengthens Lilly's hematology pipeline and reflects the company's focus on next-generation targeted therapies for unmet medical needs.
- Novartis acquires Synnovation’s PI3Kα breast cancer drug in multi-billion dollar deal
Novartis has acquired a unit of privately held Synnovation Therapeutics for up to $3 billion, securing a promising PI3Kα inhibitor aimed at treating breast cancers driven by PIK3CA mutations.
- Lilly warns of dangerous impurities in tirzepatide knockoff compounds
Eli Lilly has raised concerns about high levels of impurities found in compounded versions of tirzepatide, a GLP-1 receptor agonist used for obesity treatment. The company warns that these knockoff formulations, some combined with vitamin B12, may pose safety risks to patients.
- Recent clinical advances in therapies for muscular disorders show promising efficacy and safety
Three biotech companies have reported encouraging clinical data for therapies targeting muscular disorders.
- BioNTech founders to leave and launch new next-generation mRNA company
BioNTech CEO Uğur Şahin and CMO/co-founder Özlem Türeci plan to depart the company by the end of the year to start a new venture focused on next-generation mRNA innovations.
- FDA intensifies scrutiny of compounded GLP-1 drugs and novo nordisk ads
The FDA has ramped up its crackdown on compounded GLP-1 drugs, issuing 30 warning letters to pharmacies. Novo Nordisk faces regulatory scrutiny over its GLP-1 ads, while Intellia is set to restart a heart disease trial.
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