Signal
Human Genetic Analysis Reveals Circulating Alpha-1 Antitrypsin Level as a Protective Factor in Sepsis
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Evidence preview
- Inter-individual variability in lipoprotein proteomics reveals distinct patient clusters informative for disease path...medRxiv (all subjects)
- Human Genetic Analysis Reveals Circulating Alpha-1 Antitrypsin Level as a Protective Factor in SepsismedRxiv (all subjects)
Overview
Sepsis is a dysregulated host response to infection and a leading cause of global mortality, yet effective targeted therapies remain lacking. Here, we applied a proteogenomic framework integrating large-scale human genetics with circulating proteomics to identify therapeutic targets.
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