Signal
Sun2 protein links nuclear mechanosensing to fibrosis progression in skin and lung
Recent studies reveal that Sun2, a nuclear membrane protein part of LINC complexes, plays a critical role in fibrosis by mediating stiffness-dependent nuclear and chromatin responses.
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- bioRxiv preprints on Sun2 and fibrosisbiorxiv.org
- Loss of Sun2 ablates nuclear mechanosensing-driven extracellular matrix production and mitigates lung fibrosisbioRxiv (all subjects)