Signal
ATM deficiency impacts DNA replication and repair mechanisms involving BRCA1-A complex
Recent preprints reveal how ATM kinase deficiency affects DNA replication and repair, influencing cancer cell sensitivity to chemotherapy. One study shows that ATM inhibition triggers BRCA1-A complex-mediated restriction of replication fork reversal, leading to hypersensitivity to Topoisomerase I inhibitors.
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- bioRxiv preprints on ATM and BRCA1-A in DNA repairbiorxiv.org
- ATM safeguards DNA replication at endogenous base lesionsbioRxiv (all subjects)